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- Document 3063
- DOCN M94A3063
- TI Anti-p24 titer: a marker for AIDS in Cuban HIV seropositives.
- DT 9412
- AU Benitez J; Rivero J; CIGB, Havana, Cuba.
- SO Int Conf AIDS. 1994 Aug 7-12;10(1):162 (abstract no. PB0076). Unique
- Identifier : AIDSLINE ICA10/94369512
- AB OBJECTIVE: To evaluate the use of anti-p24 antibody titer as a marker
- for the prognosis of AIDS in Cuban HIV-1 seropositives. METHODS: An
- ELISA for anti-p24 titration, based on recombinant HIV-1 p24, which uses
- a protein-A-peroxidase conjugate was used. Serum samples were 1:2
- serially diluted from 1:20 to 1:2560. Both the titer and the slope of
- the dilution curve were calculated. Anti-p24 antibody titers were
- quantified for 852 samples from 234 HIV infected individuals
- representative of all the stages of the infection, and in the
- longitudinal study, serum samples from 135 patients were sequentially
- evaluated for 36 months. RESULTS AND CONCLUSIONS: Titers lower than
- 1:160 were obtained for 84.8% of the AIDS patients, and statistical
- significant differences were found between AIDS cases and group II (p <
- 0.00006) and group III cases (p < 0.00003). In 36 group II or III
- patients, a decrease of the anti-p24 titer was observed prior to or in
- correlation with disease progression. We conclude that (1) p24 low
- responders are at higher risk for AIDS than high responders. (2)
- Anti-p24 titer is an accurate marker for the progression to AIDS, and
- represent an economical alternative for the follow up of HIV
- seropositives in developing countries.
- DE Acquired Immunodeficiency Syndrome/CLASSIFICATION/*DIAGNOSIS/
- IMMUNOLOGY AIDS Serodiagnosis/ECONOMICS Cost-Benefit Analysis Cuba
- *Developing Countries Enzyme-Linked Immunosorbent Assay/ECONOMICS
- Follow-Up Studies Human HIV Antibodies/*BLOOD HIV Core Protein
- p24/*IMMUNOLOGY HIV Seropositivity/CLASSIFICATION/*DIAGNOSIS/IMMUNOLOGY
- HIV-1/*IMMUNOLOGY Longitudinal Studies MEETING ABSTRACT
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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-